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Research

Despite several calls for greater inclusion of pregnant people in non-obstetric clinical trials, their systematic exclusion remains common practice. Excluding pregnant individuals from clinical trials may result in unintended consequences such as inadequate treatment of medical conditions in pregnancy, inappropriate dosing of medications, and investigational therapies being used off-label outside of the context of a clinical trial, risking adverse events in the absence of demonstrated efficacy.

Research

Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection.

Research

There is no consensus on how best to measure responses to interventions among children and adults with cystic fibrosis (CF). We have systematically reviewed and summarised the characteristics and measurement properties of tests and tools that have been used to capture outcomes in studies among people with CF, including their reliability, validity and responsiveness. This review is intended to guide researchers when selecting tests or tools for measuring treatment effects in CF trials. A consensus set of these tests and tools could improve consistency in how outcomes are captured and thereby facilitate comparisons and synthesis of evidence across studies.

Learn more about the Wesfarmers Centre of Vaccines and Infectious Diseases

To improve the health of the community through immunisation and prevention of infectious diseases, we are conducting clinical trials of vaccines.

The CHIP Study investigates how burn injuries in children affect their immune system.

Allergies have been on the rise in Australia over the past 20 years, with three out of every 10 babies born each year now developing a food-related allergy or eczema by their first birthday. OPTIMUM: OPTimising IMunisation Using Mixed schedules In

Contact us If you'd like to get in touch, please contact us by phone or email. Phone: 0400 450 240 Email: vtg@thekids.org.au The Vaccine Trials Group will be busier than ever in 2021, with a number of new studies due to get underway in the new year.

CMVictory: finding a vaccine for cytomegalovirus, a serious virus for unborn babies

Māori and Pacific governance groups discuss and inform study protocols and issues that have arisen during the study, particularly those pertaining to Māori and Pacific ARF patients and their whānau.